The mechanisms of action of probiotics are characterized by the joint affect of all spectrum of constituent components on the human organism.
Bifidobacterium and Lactobacillus possess the multiple-factor regulative and stimulant affect on human organism. Their balance and correct localization in the intestine play an important role.
In common they realize the followings functions:
○ protect the microflora of intestine from invasion by pathogenic and conditionally pathogenic microorganisms, influence them antagonistically by the products of their metabolism: by organic acids, hydrogen peroxide, lysozyme and other bioactive and antibiotic like substances;
○ activate the immune system, regulating the functions of humoral and cellular immunity;
○ participate in digestion: metabolize different substrates of vegetable, animal and microbal origin, ferment carbonhydrates, in particular lactose (milk-sugar), proteins, slit urea; synthesize volatile fat acids, vitamins, amino acid, hormones;
○ normalize metabolism - regulate water-salt and gas exchange, processes of intestinal absorption, promote assimilation of calcium ions, iron, vitamin D, participate in recirculation of bile acids, influence on metabolism of bilirubin and cholesterol;
○ provide detoxication of organism - destroy toxins, radioactive nuclides, xenobiotics, inactivate Histamines, pro-carcinogenic and mutagene substances.
Cultures, belonging to the structure of preparations, possess the well-proven probiotic properties, high antagonistic activity in regard to pathogenic, conditionally pathogenic microorganisms, putrefactive microorganism, rotaviruses, resistance to the antibiotics and hydrochloric acid of gastric content.“all cultures possess synergism regarding each other“
Complex of Bifidobacterium and Lactobacillus is selected, taking into account the features of composition of microflora of every age group. Such approach not only summarizes effect of separate cultures but also favours to stable localization or new colonization of intestine by those types of bacteria which prevail in the microbiocenosis of concrete human being.
Indications for application of probiotic:
○ disturbance of gastrointestinal tract microflora, caused by acute and chronic infections, affections of digestive system, helminthic invasion, by the reception of antibiotics and other factors, which balefully influence the normal microflora;
○ vitamin deficiency;
○ increased physical and mental loadings;
○ change of dietary habits;
○ prophylaxis of dysbiotic violations of gastrointestinal tract.
Probiotics are prescribed children, ailing often, in periods, preceding periods of rise of respiratory diseases.
Besides, probiotics can be used as generally restorative medicine.